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Roos, Raymond P.
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overview Dr Roos is the Marjorie and Robert E. Straus Professor in Neurological Science in the Department of Neurology. His research program is focused on the pathogenesis of neurodegenerative diseases, especially amyotrophic lateral sclerosis, and on investigations of picornavirus central nervous system infections. He has published more than 200 papers. Dr. Roos previously served as Chair of the Department of Neurology. He has been a member of the Editorial Boards of the J. Neuroimmunology, J. Neurovirology, J. Virology, and Annals of Neurology, and presently serves on the Editorial Board of Virology and Scientific Reports. He is Associate Editor of Neurology Genetics and Editor-in-Chief of MedLink (an on-line Neurology site). He is a member of the US FDA Cellular, Tissues and Gene Therapies Advisory Committee. He formerly served as Chair of the FDA Transmissible Spongiform Encephalopathies Committee as well as the Chair of the Vaccines and Related Biological Products Advisory Committee. He was a member of the National Academy of Sciences Institute of Medicine Committee to Examine Multiple Sclerosis, American Academy of Neurology Science Committee, Amyotrophic Lateral Sclerosis (ALS) Association grant review committee, National Multiple Sclerosis Society Research Programs Advisory Committee (which he Chaired), and NIH NINDS grant review study section.
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Item TypeName
Concept Acquired Immunodeficiency Syndrome
Concept Amyotrophic Lateral Sclerosis
Concept Alleles
Concept Amino Acid Sequence
Concept Central Nervous System Diseases
Concept Computer Simulation
Concept Antibody Specificity
Concept Antilymphocyte Serum
Concept Base Sequence
Concept Binding Sites
Concept Electric Stimulation
Concept Brain Stem
Concept Central Nervous System
Concept Immune System
Concept Sleep Initiation and Maintenance Disorders
Concept DNA, Recombinant
Concept Lac Operon
Concept Cross-Sectional Studies
Concept Disease Susceptibility
Concept Genes, Dominant
Concept Genes, Viral
Concept Injections, Spinal
Concept Life Support Care
Concept Home Care Services
Concept Mice, Inbred Strains
Concept Muscular Atrophy, Spinal
Concept Molecular Sequence Data
Concept Repetitive Sequences, Nucleic Acid
Concept Herpes Simplex
Concept Nervous System Diseases
Concept Synaptic Transmission
Concept Nucleic Acid Conformation
Concept Peripheral Nervous System Diseases
Concept Peripheral Nervous System Neoplasms
Concept Stress, Physiological
Concept Sural Nerve
Concept Surface-Active Agents
Concept Templates, Genetic
Concept Species Specificity
Concept Scrapie
Concept Paraparesis, Tropical Spastic
Concept Serpins
Concept Solubility
Concept Schwann Cells
Concept Seasons
Concept Sepharose
Concept Creutzfeldt-Jakob Syndrome
Concept Subarachnoid Hemorrhage
Concept Sensitivity and Specificity
Concept Mass Spectrometry
Concept Spinal Diseases
Concept Sheep
Concept Sympathetic Nervous System
Concept Gerstmann-Straussler-Scheinker Disease
Concept Superoxides
Concept Surgical Instruments
Concept Synapses
Concept United States
Concept Subacute Sclerosing Panencephalitis
Concept Superoxide Dismutase
Concept Syndrome
Concept Sequence Homology, Amino Acid
Concept Hereditary Sensory and Motor Neuropathy
Concept Viral Structural Proteins
Concept Spinal Muscular Atrophies of Childhood
Concept Genes, Tumor Suppressor
Concept Genome, Viral
Concept Lupus Erythematosus, Systemic
Concept Multiple Sclerosis
Concept Rats, Sprague-Dawley
Concept Mutagenesis, Site-Directed
Concept Case-Control Studies
Concept Postpoliomyelitis Syndrome
Concept Genes, pX
Concept Alternative Splicing
Concept In Situ Hybridization
Concept Protein Structure, Tertiary
Concept Myelin Sheath
Concept Ubiquitin Thiolesterase
Concept Consensus Sequence
Concept Sequence Deletion
Concept Oxidative Stress
Concept Muscle, Skeletal
Concept Transgenes
Concept Staurosporine
Concept Metabolic Syndrome
Concept Reactive Oxygen Species
Concept Endoplasmic Reticulum Stress
Concept Ribosomal Protein S6 Kinases
Concept Amino Acid Substitution
Concept 5' Untranslated Regions
Concept Surveys and Questionnaires
Concept Serum Albumin
Concept Severity of Illness Index
Concept Schizophrenia
Concept Glycogen Synthase Kinases
Concept Glycogen Synthase Kinase 3
Concept Sleep Apnea Syndromes
Concept Socioeconomic Factors
Concept Spinocerebellar Degenerations
Concept Subarachnoid Space
Concept Unfolded Protein Response
Concept Silver Nitrate
Concept Space Perception
Concept Spinal Cord Diseases
Concept Spleen
Concept SSPE Virus
Concept Serine Proteinase Inhibitors
Concept Survival Analysis
Concept Open Reading Frames
Concept Tuberous Sclerosis
Concept Patient Satisfaction
Concept Nitric Oxide Synthase
Concept MAP Kinase Signaling System
Concept Protein Sorting Signals
Concept Protein Stability
Concept Single-Chain Antibodies
Concept Protein Unfolding
Concept Cell Survival
Concept Follow-Up Studies
Concept Longitudinal Studies
Concept Prospective Studies
Concept Retrospective Studies
Concept Sciatic Nerve
Concept Sclerosis
Concept Spinal Cord
Concept Staining and Labeling
Concept Digestive System Surgical Procedures
Concept Simian virus 40
Concept Signal Transduction
Concept Spastic Paraplegia, Hereditary
Concept Tumor Suppressor Protein p53
Concept Mice, SCID
Concept Encephalopathy, Bovine Spongiform
Concept Conserved Sequence
Concept Polymorphism, Single Nucleotide
Concept Macromolecular Substances
Concept Muscle Strength
Academic Article Immune responses in the post-polio syndrome.
Academic Article Home ventilation for amyotrophic lateral sclerosis patients: outcomes, costs, and patient, family, and physician attitudes.
Academic Article p53 expression induces apoptosis in hippocampal pyramidal neuron cultures.
Academic Article Chimeric cDNA studies of Theiler's murine encephalomyelitis virus neurovirulence.
Academic Article Molecular characterization of a nondemyelinating variant of Daniel's strain of Theiler's virus isolated from a persistently infected glioma cell line.
Academic Article Patients with amyotrophic lateral sclerosis receiving long-term mechanical ventilation. Advance care planning and outcomes.
Academic Article Viral meningitis and encephalitis.
Academic Article Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection.
Academic Article Human T-cell lymphotropic virus type-I infection in the severe combined immunodeficiency mouse.
Academic Article A neutralization site of DA strain of Theiler's murine encephalomyelitis virus important for disease phenotype.
Academic Article The regulation of gene expression in neurotrophic viruses.
Academic Article Amyotrophic lateral sclerosis and viruses.
Academic Article The effect of Theiler's murine encephalomyelitis virus (TMEV) VP1 carboxyl region on the virus-induced central nervous system disease.
Academic Article What happens when mutant neuroserpins get into bad shape.
Academic Article Theiler's murine encephalomyelitis virus-induced cardiac and skeletal muscle disease.
Academic Article Molecular determinants for virulence in coxsackievirus B1 infection.
Academic Article The CD4-mediated immune response is critical in determining the outcome of infection using Theiler's viruses with VP1 capsid protein point mutations.
Academic Article Influence of Theiler's murine encephalomyelitis virus 5' untranslated region on translation and neurovirulence.
Academic Article Central nervous system cytokine mRNA expression following Theiler's murine encephalomyelitis virus infection.
Academic Article L* protein of the DA strain of Theiler's murine encephalomyelitis virus is important for virus growth in a murine macrophage-like cell line.
Academic Article Effect of adenovirus-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage.
Academic Article A Theiler's virus alternatively initiated protein inhibits the generation of H-2K-restricted virus-specific cytotoxicity.
Academic Article The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis.
Academic Article The prion diseases.
Academic Article Controlling new prion diseases.
Academic Article Creutzfeldt-Jakob disease, new variant creutzfeldt-jakob disease, and bovine spongiform encephalopathy.
Academic Article The role of beta-catenin stability in mutant PS1-associated apoptosis.
Academic Article Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
Academic Article Intrafamilial heterogeneity in hereditary motor neuron disease.
Academic Article Novel mutations in spastin gene and absence of correlation with age at onset of symptoms.
Academic Article Direct evidence of a role for amino acid 101 of VP-1 in central nervous system disease in Theiler's murine encephalomyelitis virus infection.
Academic Article Cell-specific proteins regulate viral RNA translation and virus-induced disease.
Academic Article Mixed lineage kinase 3 mediates gp120IIIB-induced neurotoxicity.
Academic Article "Out, damned spot! out, I say!...": issues related to prion decontamination.
Academic Article A rare Cu/Zn superoxide dismutase mutation causing familial amyotrophic lateral sclerosis with variable age of onset, incomplete penetrance and a sensory neuropathy.
Academic Article Membrane lymphotoxin is required for resistance to Theiler's virus infection.
Academic Article Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells.
Academic Article Using a roster and haplotyping is useful in risk assessment for persons with intermediate and reduced penetrance alleles in Huntington disease.
Academic Article Pathogenesis of early and late disease in mice infected with Theiler's virus, using intratypic recombinant GDVII/DA viruses.
Academic Article Failure to detect poliovirus genetic information in amyotrophic lateral sclerosis.
Academic Article Failure to detect enterovirus in the spinal cord of ALS patients using a sensitive RT-PCR method.
Academic Article Determinants of measles virus (hamster neurotropic strain) replication in mouse brain.
Academic Article Molecular mechanisms of attenuation of the Sabin strain of poliovirus type 3.
Academic Article Truncated wild-type SOD1 and FALS-linked mutant SOD1 cause neural cell death in the chick embryo spinal cord.
Academic Article Polyclonal IgM anti-GM1 ganglioside antibody in patients with motor neuron disease and variants.
Academic Article Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models.
Academic Article CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice.
Academic Article Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse.
Academic Article Intrathecal interferon in subacute sclerosing panencephalitis.
Academic Article An elderly patient with Bickerstaff brainstem encephalitis and transient episodes of brainstem dysfunction.
Academic Article Alternative translation initiation site in the DA strain of Theiler's murine encephalomyelitis virus.
Academic Article Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus.
Academic Article Trypsin-sensitive neutralization site on VP1 of Theiler's murine encephalomyelitis viruses.
Academic Article Viruses and dementia.
Academic Article Theiler's murine encephalomyelitis virus L* amino acid position 93 is important for virus persistence and virus-induced demyelination.
Academic Article Different strains of Theiler's murine encephalomyelitis virus antagonize different sites in the type I interferon pathway.
Academic Article Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice.
Academic Article Strains from both Theiler's virus subgroups encode a determinant for demyelination.
Academic Article Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology.
Academic Article Localization of a neutralization site of Theiler's murine encephalomyelitis viruses.
Academic Article Apoptotic and antiapoptotic activity of L protein of Theiler's murine encephalomyelitis virus.
Academic Article The L-coding region of the DA strain of Theiler's murine encephalomyelitis virus causes dysfunction and death of myelin-synthesizing cells.
Academic Article Restricted heterogeneity of antibody to gp120 and p24 in AIDS.
Academic Article A subgenomic segment of Theiler's murine encephalomyelitis virus RNA causes demyelination.
Academic Article Genetically controlled resistance to virus infections of the central nervous system.
Academic Article HTLV-I-associated myelopathy: oligoclonal immunoglobulin G bands contain anti-HTLV-I p24 antibody.
Academic Article Oligoclonal IgG in rabbits with experimental allergic encephalomyelitis: non-reactivity of the bands with sensitizing neural antigens.
Academic Article Characterization of a cell culture persistently infected with the DA strain of Theiler's murine encephalomyelitis virus.
Academic Article Function and ultrastructure of the neuromuscular junction in post-polio syndrome.
Academic Article Attempt to identify the agent for Creutzfeldt-Jakob disease by CF antibody relationship to known viruses.
Academic Article Human immunodeficiency virus gp120 and p24 oligoclonal antibody in acquired immunodeficiency syndrome cerebrospinal fluid and sera.
Academic Article Mutant SOD1 forms ion channel: implications for ALS pathophysiology.
Academic Article Amyotrophic lateral sclerosis with antecedent poliomyelitis.
Academic Article Spinal cord: motor neuron diseases.
Academic Article The antibody response in Theiler's virus infection: new perspectives on multiple sclerosis.
Academic Article Characterization and specificity of humoral immune responses to Theiler's murine encephalomyelitis virus capsid proteins.
Academic Article Immunoglobulin studies in patients with psychiatric diseases.
Academic Article Detection of visna virus antigens and RNA in glial cells in foci of demyelination.
Academic Article HTLV-I hu-SCID mouse in the study of HTLV-I neurotropism.
Academic Article The clinical characteristics of transmissible Creutzfeldt-Jakob disease.
Academic Article Relationship of Theiler's murine encephalomyelitis viruses to the cardiovirus genus of picornaviruses.
Academic Article Oligoclonal IgG bands in cerebrospinal fluid and serum during asymptomatic human immunodeficiency virus infection.
Academic Article Coexistence of amyotrophic lateral sclerosis and Werdnig-Hoffmann disease within a family.
Academic Article Post-poliomyelitis syndrome: evidence of ongoing denervation in symptomatic and asymptomatic patients.
Academic Article B-cell abnormalities in multiple sclerosis. A hypothesis.
Academic Article An isoelectric focusing overlay study of the humoral immune response in Theiler's virus demyelinating disease.
Academic Article Immunology of multiple sclerosis.
Academic Article Viruses and demyelinating disease of the central nervous system.
Academic Article Neuropathy accompanying IgM lambda monoclonal gammopathy.
Academic Article Neurovirulence determinants of genetically engineered Theiler viruses.
Academic Article Comparison of agar gel electrophoresis and isoelectric focusing in multiple sclerosis and subacute sclerosing panencephalitis.
Academic Article Cerebrospinal fluid and serum oligoclonal IgG bands in rabbits with experiment allergic encephalomyelitis.
Academic Article Light chain composition of CSF oligoclonal IgG bands in multiple sclerosis and subacute sclerosing panencephalitis.
Academic Article Isoelectric focusing of IgG eluted from multiple sclerosis and subacute sclerosing panencephalitis brains.
Academic Article A picornaviral protein synthesized out of frame with the polyprotein plays a key role in a virus-induced immune-mediated demyelinating disease.
Academic Article Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth factor.
Academic Article Molecular cloning and sequence determination of DA strain of Theiler's murine encephalomyelitis viruses.
Academic Article Immunoperoxidase staining of cerebrospinal fluid IgG in isoelectric focusing gels: a sensitive new technique.
Academic Article Silver staining of cerebrospinal fluid IgG in isoelectric focusing gels.
Academic Article The post-polio syndrome: evaluation and treatment.
Academic Article Antibody titer to the poliovirus in blood and cerebrospinal fluid of patients with post-polio syndrome.
Academic Article First experimental transmission of fatal familial insomnia.
Academic Article Biochemical analysis of DA strain of Theiler's murine encephalomyelitis virus obtained directly from acutely infected mouse brain.
Academic Article Theiler's virus as a vector for foreign gene delivery.
Academic Article Selective knockdown of mutant SOD1 in Schwann cells ameliorates disease in G85R mutant SOD1 transgenic mice.
Academic Article Regulation of excitatory transmission at hippocampal synapses by calbindin D28k.
Academic Article Oligoclonal IgG in multiple sclerosis and subacute sclerosing panencephalitis brains.
Academic Article A single amino acid change determines persistence of a chimeric Theiler's virus.
Academic Article Oligoclonal IgA bands in multiple sclerosis and subacute sclerosing panencephalitis.
Academic Article Neuromuscular transmission in amyotrophic lateral sclerosis.
Academic Article Isolation of an adenovirus 32 strain from human brain in a case of subacute encephalitis.
Academic Article Familial spastic paraparesis syndrome associated with HTLV-I infection.
Academic Article The effect of short-term and chronic immunosuppression on Theiler's virus demyelination.
Academic Article The leader peptide of Theiler's murine encephalomyelitis virus is a zinc-binding protein.
Academic Article Intracerebral distribution of infectious amyloid protein in spongiform encephalopathy.
Academic Article The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis.
Academic Article Isoelectric focusing studies of serum and cerebrospinal fluid in patients with antecedent poliomyelitis.
Academic Article GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity.
Academic Article Viral infectious complementary-DNA studies may identify nonviral genes critical to central nervous system disease.
Academic Article Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.
Academic Article The unfolded protein response in familial amyotrophic lateral sclerosis.
Academic Article Impaired glucose tolerance and metabolic syndrome in idiopathic polyneuropathy: the role of pain and depression.
Academic Article Linkage analysis in familial amyotrophic lateral sclerosis.
Academic Article Sleep apnea in olivopontocerebellar degeneration: treatment with trazodone.
Academic Article Nucleic acid probes in the study of amyotrophic lateral sclerosis.
Academic Article An immunological and cytogenetic investigation of tuberous sclerosis.
Academic Article DA strain of Theiler's murine encephalomyelitis virus induces demyelination in nude mice.
Academic Article Molecular determinants of Theiler's murine encephalomyelitis-induced disease.
Academic Article Circulating immune complexes in neurologic disease.
Academic Article Search for retrovirus in patients with multiple sclerosis.
Academic Article Ca2+ and reactive oxygen species in staurosporine-induced neuronal apoptosis.
Academic Article Involvement of cardiovirus leader in host cell-restricted virus expression.
Academic Article Neuromuscular transmission as a function of motor unit size in patients with prior poliomyelitis.
Academic Article A protein critical for a Theiler's virus-induced immune system-mediated demyelinating disease has a cell type-specific antiapoptotic effect and a key role in virus persistence.
Academic Article Adenoviral gene transfer of nitric oxide synthase increases cerebral blood flow in rats.
Academic Article No correlation between aggregates of Cu/Zn superoxide dismutase and cell death in familial amyotrophic lateral sclerosis.
Academic Article Wrinkles and folds of the prion protein.
Academic Article Kappa light chain predominance in serum and cerebrospinal fluid from human immunodeficiency virus type 1 (HIV-1)-infected patients.
Academic Article Amyotrophic lateral sclerosis and life-sustaining therapy: patients' desires for information, participation in decision making, and life-sustaining therapy.
Academic Article Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase.
Academic Article Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neurons.
Academic Article An isoelectric focusing study in herpes simplex virus encephalitis.
Academic Article Sciatic endometriosis: a treatable sensorimotor mononeuropathy.
Academic Article Creutzfeldt-Jakob disease: a case-control study.
Academic Article Analysis of Theiler's virus isolates from persistently infected mouse nervous tissue.
Academic Article Immunologic and virologic studies of measles inclusion body encephalitis in an immunosuppressed host: the relationship to subacute sclerosing panencephalitis.
Academic Article CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses.
Academic Article The hypothalamic lateral tuberal nucleus in Alzheimer's disease.
Academic Article Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1.
Academic Article Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants.
Academic Article Venous thromboembolism after diaphragm pacing in amyotrophic lateral sclerosis.
Academic Article Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis.
Academic Article An enhanced integrated stress response ameliorates mutant SOD1-induced ALS.
Academic Article Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function.
Academic Article Neoplastic cauda equina syndrome: a neuroimaging-based review.
Academic Article D. CARLETON GAJDUSEK.
Academic Article Visuospatial Processing Deficits Linked to Posterior Brain Regions in Premanifest and Early Stage Huntington's Disease.
Academic Article Intermuscular coherence in amyotrophic lateral sclerosis: A preliminary assessment.
Academic Article Gastrostomy tube placement is safe in advanced amyotrophic lateral sclerosis.
Academic Article Long-term follow-up after surgery for simple and complex cryptoglandular fistulas: fecal incontinence and impact on quality of life.
Academic Article S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects.
Academic Article Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS.
Academic Article Genetic linkage studies in Huntington disease.
Academic Article Evidence for an early innate immune response in the motor cortex of ALS.
Award or Honor Receipt Fellow in Medical Science
Award or Honor Receipt Society for Scholars
Award or Honor Receipt Dr. Frank L. Babbott, MD Memorial Award
Academic Article [Osteogenesis imperfecta associated with dentinogenesis imperfecta].
Academic Article TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.
Academic Article Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS.
Academic Article A Masked Marauder: Hepatitis C Neuropathy.
Academic Article Translation of dipeptide repeat proteins from the C9ORF72 expanded repeat is associated with cellular stress.
Academic Article Single chain variable fragment antibodies directed against SOD1 ameliorate disease in mutant SOD1 transgenic mice.
Grant Combating stress in G85R ALS mice
Grant A C. elegans model to study the disease-producing effects of dipeptide repeats from the C9ORF72 locus
Academic Article Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS.
Academic Article RNA-binding protein altered expression and mislocalization in MS.
Academic Article A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
Academic Article Machine learning predicts translation initiation sites in neurologic diseases with nucleotide repeat expansions.
Academic Article Kozak Similarity Score Algorithm Identifies Alternative Translation Initiation Codons Implicated in Cancers.
Concept Superoxide Dismutase-1
Concept Spastin
Concept Prodromal Symptoms
Concept S100 Calcium Binding Protein G
Concept Visual Analog Scale
Academic Article Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons.
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